反应详情

3-(4-Hydroxyphenyl)propionic acid (5 g), potassium carbonate (16 g) and tetrahydrofuran (50 ml) were placed in a three-necked flask, 8.5 ml of benzyl bromide was added dropwise through a syringe under stirring, and the mixture was heated under reflux overnight. After filtering off the solid matters, the solvent was distilled off, and the residue was purified by column chromatography on silica gel (50 g), affording 9.25 g (89.3%) of pure benzyl 3-(4-benzyloxyphenyl)propionate.

1. temperaturethe mixture was heated
2. temperatureunder reflux overnight
3. filtrationAfter filtering off the solid matters
4. distillationthe solvent was distilled off
5. customthe residue was purified by column chromatography on silica gel (50 g)