Hydrazine hydrate (1:1) → HCID 12926539, compound

HRID 867930Notes

Reaction equation

HRID 867930 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[S:9][C:8]([S:10][CH2:11][CH2:12][CH2:13][N:14]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:7][C:6]=1[CH3:25])[CH3:3].O.NN>O1CCCC1>[NH2:14][CH2:13][CH2:12][CH2:11][S:10][C:8]1[S:9][C:5]([CH2:4][N:2]([CH3:1])[CH3:3])=[C:6]([CH3:25])[CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21289082HCID 21289082, compound

Product 1

HCID 12926539HCID 12926539, compoundYield 69.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

N-[3-[[5-(Dimethylamino)methyl-4-methyl-2-thienyl]thio]propyl]isoindole-1,3(2H)-dione (15.2 g) and hydrazine hydrate (8 ml) were stirred at room temperature in tetrahydrofuran (150 ml) for 48 h. The mixture was filtered and the filtrate was distilled to give the title compound as an orange oil (6.9 g) b.p. 160°-170°/0.04 mm.

Workup

  1. filtrationThe mixture was filtered
  2. distillationthe filtrate was distilled

Sources & evidence

ORD record
ord-72a386c20f89462881e04b5b20089621
Source dataset
uspto-grants-1988_10
Patent number
US04777179

Reaction notes

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