Sodium Sulfite → HCID 66643213, compound

HRID 869230Notes

Reaction equation

HRID 869230 reaction equation
C(S[C:5]1[CH:10]=[CH:9][C:8](C)=[CH:7][C:6]=1[N+:12]([O-:14])=[O:13])(C)C.Cl[C:16]1[CH:21]=CC=C(C(OO)=O)[CH:17]=1.[C:26](=O)([O-])O.[Na+].[S:31]([O-:34])([O-])=[O:32].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH:16]([S:31]([C:7]1[CH:8]=[C:9]([CH3:26])[CH:10]=[CH:5][C:6]=1[N+:12]([O-:14])=[O:13])(=[O:34])=[O:32])([CH3:21])[CH3:17]

Participants

6

Reactant 4

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 516892Sodium BicarbonateHCID 66642914HCID 66642914, compound

Product 1

HCID 66643213HCID 66643213, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
50 °C

Procedure

To a mixture of 1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene (Preparation Example 287) (6.60 g) and chloroform (150 mL), m-chloroperbenzoic acid (18.0 g) was added and stirred at 50° C. for 12 hours. After the reaction liquid was cooled, saturated aqueous sodium hydrogen carbonate and 5% aqueous sodium sulfite were added, and the reaction liquid was extracted with chloroform. After the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to give 2-(isopropylsulfonyl)-4-methyl-1-nitrobenzene (7.41 g) as a yellow solid.

Workup

  1. additionwas added
  2. customAfter the reaction liquid
  3. temperaturewas cooled
  4. customthe reaction liquid
  5. extractionwas extracted with chloroform
  6. dry with materialAfter the organic layer was dried over anhydrous sodium sulfate
  7. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-a78fc81410f045249dfdb20a289d0faf
Source dataset
uspto-grants-2015_03
Patent number
US08969336B2

Reaction notes

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