Bicarbonate Ion → Methyl 8-[1-[3,5-bis(trifluoromethyl)phenyl]ethyl-methylcarbamoyl]-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate
Reaction equation
[CH2:57]([SiH:58]([CH2:59][CH3:60])[CH2:61][CH3:62])[CH3:63].[Cl:69][CH2:70][Cl:71].[F:1][C:2]([c:3]1[cH:4][c:5]([CH:13]([CH3:14])[N:15]([C:16](=[O:17])[N:18]2[CH:19]([c:39]3[c:40]([CH3:46])[cH:41][c:42]([F:45])[cH:43][cH:44]3)[CH2:20][C:21]([NH:24][S:26]([C:27]([CH3:28])([CH3:29])[CH3:30])=[O:38])([CH2:31][CH2:32][C:33](=[O:25])[C:34](=[O:35])[O:36][CH3:37])[CH2:22][CH2:23]2)[CH3:47])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:48])[F:49].[F:50][C:51]([F:52])([F:53])[C:54]([OH:55])=[O:56].[Na+:68].[O-:64][C:65]([OH:66])=[O:67]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH:13]([CH3:14])[N:15]([C:16](=[O:17])[N:18]2[CH:19]([c:39]3[c:40]([CH3:46])[cH:41][c:42]([F:45])[cH:43][cH:44]3)[CH2:20][C:21]3([CH2:22][CH2:23]2)[NH:24][CH:33]([C:34](=[O:35])[O:36][CH3:37])[CH2:32][CH2:31]3)[CH3:47])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:48])[F:49]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-681edeb37799459a8234fdf713c906ce
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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