1,2-Dibromoethane → 9-(2-Bromoethyl)-2-butoxy-8-methoxy-9H-purin-6-amine

HRID 869360Notes

Reaction equation

HRID 869360 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([O:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([O:22][CH3:23])[NH:19]2)=[C:15]([NH2:24])[N:14]=1)[CH2:9][CH2:10][CH3:11].C(=O)([O-])[O-].[K+].[K+].[Br:31][CH2:32][CH2:33]Br>CN(C)C=O>[Br:31][CH2:32][CH2:33][N:19]1[C:18]([O:22][CH3:23])=[N:17][C:16]2[C:20]1=[N:21][C:13]([O:12][CH2:8][CH2:9][CH2:10][CH3:11])=[N:14][C:15]=2[NH2:24]

Participants

5

Reactant 3

HCID 78391,2-DibromoethaneHCID 11430Potassium CarbonateHCID 178450370HCID 178450370, compound

Product 1

HCID 589428939-(2-Bromoethyl)-2-butoxy-8-methoxy-9H-purin-6-amine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Example 2-1 step (v) (2 g), potassium carbonate (3.7 g) and 1,2-dibromoethane (0.6 ml) were added to dimethylformamide (20 ml), and the same manner to Example 2-13 step (i) was conducted to give the titled compound as a cream colored solid. Yield: 1.2 g (62%).

Sources & evidence

ORD record
ord-592d3cb600b048e3b2c956eb6392f8cd
Source dataset
uspto-grants-2015_03
Patent number
US08969362B2

Reaction notes

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