Isobutyric Acid → Benzoic Acid

Temperature

-10 °C

To compound (L-2) (14.16 g, 61.0 mmol) in a second dry round bottom flask under N2 is added 70 mL of dry THF. The mixture is cooled to about −10° C. To the cold mixture is slowly added isopropyl magnesium chloride (63.3 ml, 2 M, 127 mmol). The resulting mixture is then stirred at −10° C. for about 20 min. Then, this mixture is slowly cannulated drop wise into the flask containing the (L-1) reaction while maintaining the temperature at −20° C. After addition is complete, the reaction is slowly warmed to RT and stirred at RT for about 1.6 hours. The reaction mixture is then cooled to −10° C. and quickly cannulated to another flask containing 15 mL of ethyl acetate and 10 mL of isobutyric acid at −10° C. under N2. After stirring for about 5 minutes, 10 mL of water is rapidly added. The cooling bath is removed, and the reaction mixture is stirred for 10 minutes at RT. The mixture is transferred to a separation funnel, and water (200 mL) is added. The water layer is extracted with EtOAc (3×400 mL). The aqueous layer is then acidified with HCl (2M) to pH 3, and is extracted with EtOAc (3×500 mL), dried over sodium sulfate and concentrated in vacuo. The resulting material is purified by silica gel column chromatography using 0-10% MeOH in DCM to afford benzoic acid (L-3).

1. additioncontaining
2. customthe (L-1) reaction
3. temperaturewhile maintaining the temperature at −20° C
4. additionAfter addition
5. temperaturethe reaction is slowly warmed to RT
6. stirringstirred at RT for about 1.6 hours
7. temperatureThe reaction mixture is then cooled to −10° C.
8. customquickly cannulated to another flask
9. stirringAfter stirring for about 5 minutes
10. customThe cooling bath is removed
11. stirringthe reaction mixture is stirred for 10 minutes at RT
12. customThe mixture is transferred to a separation funnel
13. additionwater (200 mL) is added
14. extractionThe water layer is extracted with EtOAc (3×400 mL)
15. extractionis extracted with EtOAc (3×500 mL)
16. dry with materialdried over sodium sulfate
17. concentrationconcentrated in vacuo
18. customThe resulting material is purified by silica gel column chromatography

ORD record

ord-8d47d90f9f354550b0dfa917a74ad857

Source dataset

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08969363B2