Water → HCID 86674511, compound

HRID 869691Notes

Reaction equation

HRID 869691 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[C:13]([CH3:23])=[N:14][C:15]4[C:20]([N:21]=3)=[CH:19][C:18]([F:22])=[CH:17][CH:16]=4)[CH:11]=[C:4]2[N:3]=1.[NH2:24][CH2:25][C:26]([CH3:29])([OH:28])[CH3:27].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([NH:24][CH2:25][C:26]([CH3:29])([OH:28])[CH3:27])[N:5]2[N:9]=[C:10]([C:12]3[C:13]([CH3:23])=[N:14][C:15]4[C:20](=[CH:19][C:18]([F:22])=[CH:17][CH:16]=4)[N:21]=3)[CH:11]=[C:4]2[N:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 951022-Propanol, 1-amino-2-methyl-HCID 76683609HCID 76683609, compound

Product 1

HCID 86674511HCID 86674511, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A suspension of 3-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)-6-fluoro-2-methylquinoxaline (157 mg, 0.451 mmol) in N,N-dimethylformamide (4.0 mL), 1-amino-2-methyl-propan-2-ol (48 mg, 0.541 mmol), and potassium carbonate (187 mg, 1.35 mmol) was stirred at room temperature for 2 h. The reaction mixture was poured into ice-cooled water, and the resulting precipitate was collected and washed with water to give 1-{[5-chloro-2-(7-fluoro-3-methylquinoxalin-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl]amino}-2-methylpropan-2-ol. MS (APCI): m/z 401/403 (M+H).

Workup

  1. additionThe reaction mixture was poured into ice-
  2. customthe resulting precipitate was collected
  3. washwashed with water

Sources & evidence

ORD record
ord-dcd20cbac6f146cfbe2d67602aa23372
Source dataset
uspto-grants-2015_03
Patent number
US08969376B2

Reaction notes

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