Diisopropylethylamine → HCID 58072096, compound

HRID 870539Notes

Reaction equation

HRID 870539 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:22]=[C:21]3[C:16]([CH:17]=[CH:18][CH:19]=[N:20]3)=[C:15](OS(C(F)(F)F)(=O)=O)[N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[NH2:31][CH2:32][C@H:33]1[CH2:37][NH:36][C:35](=[O:38])[CH2:34]1.C(N(C(C)C)CC)(C)C>CC(N(C)C)=O.O.CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:22]=[C:21]3[C:16]([CH:17]=[CH:18][CH:19]=[N:20]3)=[C:15]([NH:31][CH2:32][C@H:33]3[CH2:37][NH:36][C:35](=[O:38])[CH2:34]3)[N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

Participants

7

Reactant 3

HCID 81531DiisopropylethylamineHCID 51606335HCID 51606335, compoundHCID 58071952HCID 58071952, compound

Product 1

HCID 58072096HCID 58072096, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 31374DimethylacetamideSolvent

Conditions

Temperature
70 °C

Procedure

100 mg 6.1 and 30 mg of (S)-4-(aminomethyl)pyrrolidin-2-one (2.2) were dissolved in dimethylacetamide. 0.175 mL of diisopropylethylamine was added and the mixture was heated at 70° C. overnight. The mixture was diluted with water and methanol and purified via chromatography (RP-HPLC) and the corresponding fractions were freeze-dried.

Workup

  1. custompurified via chromatography (RP-HPLC)
  2. customthe corresponding fractions were freeze-dried

Sources & evidence

ORD record
ord-bd3c2bd0698a4aec9ec2bc3a511c7458
Source dataset
uspto-grants-2015_03
Patent number
US08969568B2

Reaction notes

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