2-Methoxyethylamine → HCID 66664959, compound

HRID 872318Notes

Reaction equation

HRID 872318 reaction equation
[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:19]=[C:20]4[CH:25]=[CH:24][C:23]([CH2:26]Cl)=[CH:22][N:21]4[C:28]=3[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:36][O:37][CH2:38][CH2:39][NH2:40]>C1COCC1>[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:19]=[C:20]4[CH:25]=[CH:24][C:23]([CH2:26][NH:40][CH2:39][CH2:38][O:37][CH3:36])=[CH:22][N:21]4[C:28]=3[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 66665523HCID 66665523, compound

Product 1

HCID 66664959HCID 66664959, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of {1-[4-(6-chloromethyl-3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (103 mg) and 2-methoxyethylamine (31 mg, 0.035 mL) in THF (1.1 mL) was heated at 110° C. under microwave irradiation for 1 hour. On cooling, the reaction mixture was concentrated in vacuo to give the crude title compound which was used in the next step without further purification.

Workup

  1. temperatureOn cooling
  2. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-5a30eb41a4b140379e1d56eef709e53d
Source dataset
uspto-grants-2015_03
Patent number
US08975265B2

Reaction notes

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