反应详情

温度

110 °C

A mixture of {1-[4-(7-bromo-3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (100 mg, 0.193 mmol), Pd2 dba3 (3.6 mg, 0.004 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (7 mg, 0.012 mmol), cesium carbonate (75 mg, 0.231 mmol) and methylurea (74 mg, 1.0 mmol) in dioxane (2.3 mL) and DMF (0.8 mL) was degassed, placed under an argon atmosphere and heated at 110° C. for 5 hours. On cooling, the reaction was partitioned between aqueous sodium hydrogen carbonate solution and DCM and the organic phase washed with brine, dried and concentrated in vacuo to give the crude title compound (100 mg) which was used in the next step without further purification.

1. customwas degassed
2. temperatureOn cooling
3. customthe reaction was partitioned between aqueous sodium hydrogen carbonate solution and DCM
4. washthe organic phase washed with brine
5. customdried
6. concentrationconcentrated in vacuo