Tetrahydrofuran → [4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-ylethynyl)phenyl]acetic acid methyl ester
Reaction equation
[CH2:32]([N:33]([CH2:34][CH3:35])[CH2:36][CH3:37])[CH3:38].[CH3:20][O:21][C:22]([CH2:23][c:24]1[cH:25][cH:26][c:27]([I:30])[cH:28][cH:29]1)=[O:31].[CH:1]1([c:4]2[cH:5][c:6]([C:18]#[CH:19])[cH:7][c:8]3[c:13]2[O:12][C:11]([CH3:14])([CH3:15])[CH2:10][C:9]3([CH3:16])[CH3:17])[CH2:2][CH2:3]1.[O:80]1[CH2:81][CH2:82][CH2:83][CH2:84]1.[Pd:39]([Cl:40])[Cl:41].[c:42]1([P:43]([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[cH:56][cH:57][cH:58][cH:59][cH:60]1.[c:61]1([P:62]([c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)[cH:75][cH:76][cH:77][cH:78][cH:79]1>>[CH:1]1([c:4]2[cH:5][c:6]([C:18]#[C:19][c:27]3[cH:26][cH:25][c:24]([CH2:23][C:22]([O:21][CH3:20])=[O:31])[cH:29][cH:28]3)[cH:7][c:8]3[c:13]2[O:12][C:11]([CH3:14])([CH3:15])[CH2:10][C:9]3([CH3:16])[CH3:17])[CH2:2][CH2:3]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-a20516ada2f54072862ada9b079344a2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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