Sodium hydride → HCID 71243721, compound

HRID 873179Notes

Reaction equation

HRID 873179 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:18][OH:19])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[C:13]([F:15])[C:12]([F:16])=[C:11]([F:17])[CH:10]=1.[H-].[Na+].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>C1COCC1.CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:10]=[C:11]([F:17])[C:12]([F:16])=[C:13]([F:15])[CH:14]=1)[CH2:18][O:19][C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 71239899HCID 71239899, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71243721HCID 71243721, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using (3-fluoro-4-(3,4,5-trifluorophenoxy)phenyl)methanol in THF (6 mL), sodium hydride (0.013 g, 0.323 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (0.040 g, 0.216 mmol) in DMF (1 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-1710decdc45642c2854f285060885a12
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

Loading…