Sodium hydride → HCID 71240889, compound

HRID 873182Notes

Reaction equation

HRID 873182 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][C:20]=1[F:21])[O:7][C:8]1[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][C:9]=1[C:10]#[N:11].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH:33]([CH3:35])[CH3:34])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>C1COCC1.CN(C=O)C>[F:3][C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][C:20]=1[F:21])[O:7][C:8]1[CH:15]=[CH:14][C:13]([CH2:16][O:17][C:23]2[CH:24]=[C:25]3[N:32]([CH:33]([CH3:35])[CH3:34])[CH2:31][CH2:30][N:26]3[C:27](=[O:29])[N:28]=2)=[CH:12][C:9]=1[C:10]#[N:11]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 67958464HCID 67958464, compoundHCID 86724162HCID 86724162, compound

Product 1

HCID 71240889HCID 71240889, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (16.85 mg, 0.702 mmol) in THF (4 mL), 2-(3,4-difluorophenoxy)-5-(hydroxymethyl)benzonitrile (100 mg, 0.468 mmol) in DMF (2.00 mL) and 7-chloro-1-isopropyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-49cac406645d43ccb0078296bfd4367c
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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