Sodium hydride → HCID 71243826, compound

HRID 873183Notes

Reaction equation

HRID 873183 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([CH2:16][OH:17])[CH:7]=[CH:8][C:9]=1[N:10]1[C:14]([CH3:15])=[CH:13][N:12]=[CH:11]1.Cl[C:19]1[CH:20]=[C:21]2[N:28]([CH3:29])[CH2:27][CH2:26][N:22]2[C:23](=[O:25])[N:24]=1>C1COCC1>[F:3][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][C:9]=1[N:10]1[C:14]([CH3:15])=[CH:13][N:12]=[CH:11]1)[CH2:16][O:17][C:19]1[CH:20]=[C:21]2[N:28]([CH3:29])[CH2:27][CH2:26][N:22]2[C:23](=[O:25])[N:24]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71241066HCID 71241066, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71243826HCID 71243826, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using NaH (17.46 mg, 0.727 mmol), (3-fluoro-4-(5-methyl-1H-imidazol-1-yl)phenyl)methanol (100 mg, 0.485 mmol) in THF (8 mL) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]-pyrimidin-5(1H)-one (90 mg, 0.485 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-8cec221f62b1435b97ab2a2640f303b2
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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