Sodium hydride → HCID 71243754, compound

HRID 873185Notes

Reaction equation

HRID 873185 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=2)=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18].[H-].[Na+].Cl[C:24]1[CH:25]=[C:26]2[N:33]([CH:34]([CH3:36])[CH3:35])[CH2:32][CH2:31][N:27]2[C:28](=[O:30])[N:29]=1>CN(C=O)C>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][O:14][C:24]3[CH:25]=[C:26]4[N:33]([CH:34]([CH3:36])[CH3:35])[CH2:32][CH2:31][N:27]4[C:28](=[O:30])[N:29]=3)=[CH:9][CH:8]=2)=[CH:4][C:3]=1[C:17]([F:18])([F:19])[F:20]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 66825563(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)methanolHCID 86724162HCID 86724162, compound

Product 1

HCID 71243754HCID 71243754, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using (4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol (50 mg, 0.165 mmol), NaH (11.89 mg, 0.496 mmol) in 5 mL and 7-chloro-1-isopropyl-2,3-dihydroimidazo[1,2-c]pyr-imidin-5(1H)-one (52.9 mg, 0.248 mmol) in DMF (5 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-cf9c33b872a442e1b2cfc3883023d5dd
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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