Sodium hydride → HCID 71243724, compound

HRID 873187Notes

Reaction equation

HRID 873187 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH2:21][OH:22])[CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1.Cl[C:24]1[CH:25]=[C:26]2[N:33](C(OC(C)(C)C)=O)[CH2:32][CH2:31][N:27]2[C:28](=[O:30])[N:29]=1>C1COCC1>[Cl:3][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:19])([F:20])[F:18])[CH:12]=1)[CH2:21][O:22][C:24]1[CH:25]=[C:26]2[NH:33][CH2:32][CH2:31][N:27]2[C:28](=[O:30])[N:29]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 66825535HCID 66825535, compoundHCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate

Product 1

HCID 71243724HCID 71243724, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E65 using sodium hydride (13.87 mg, 0.347 mmol), (3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)methanol in THF (8 mL) and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate (62.8 mg, 0.231 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-d7c43dbabce94ab08a63f6209d3f71d2
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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