Sodium hydride → HCID 71243755, compound

HRID 873191Notes

Reaction equation

HRID 873191 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([CH2:11][OH:12])[CH:7]=[CH:8][C:9]=1[F:10].Cl[C:14]1[CH:15]=[C:16]2[N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21][N:17]2[C:18](=[O:20])[N:19]=1>C1COCC1>[F:3][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:11][O:12][C:14]1[CH:15]=[C:16]2[NH:23][CH2:22][CH2:21][N:17]2[C:18](=[O:20])[N:19]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 5228333,4-Difluorobenzyl alcoholHCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate

Product 1

HCID 71243755HCID 71243755, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E65 using sodium hydride (44.2 mg, 1.104 mmol) in THF (5 mL), (3,4-difluorophenyl)methanol (106 mg, 0.736 mmol) and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate (100 mg, 0.368 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-4a50c04bd393466ea1ebd4f6dc277f2b
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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