Sodium hydride → HCID 71243757, compound

HRID 873196Notes

Reaction equation

HRID 873196 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[C:11]([F:12])=[CH:10][C:9]([CH2:13][OH:14])=[CH:8][C:7]=1[F:15].[H-].[Na+].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[C:7]([F:15])=[CH:8][C:9]([CH2:13][O:14][C:23]2[CH:24]=[C:25]3[N:32]([CH3:33])[CH2:31][CH2:30][N:26]3[C:27](=[O:29])[N:28]=2)=[CH:10][C:11]=1[F:12]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 63076546HCID 63076546, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71243757HCID 71243757, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using (4-(3,4-difluorophenoxy)-3,5-difluorophenyl)methanol (0.073 g, 0.269 mmol) in THF)(4 mL), sodium hydride (0.016 g, 0.404 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (0.050 g, 0.269 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-d1ed5854e4df4b8a8d598ca039ea2c9a
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

Loading…