Sodium hydride → HCID 86724212, compound

HRID 873216Notes

Reaction equation

HRID 873216 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[H-].[Na+].[Cl:15][C:16]1[CH:21]=[C:20]([O:22][C:23]2[CH:30]=[CH:29][C:28]([CH2:31][OH:32])=[CH:27][C:24]=2[C:25]#[N:26])[CH:19]=[CH:18][N:17]=1>CN(C=O)C>[Cl:15][C:16]1[CH:21]=[C:20]([O:22][C:23]2[CH:30]=[CH:29][C:28]([CH2:31][O:32][C:2]3[CH:3]=[C:4]4[N:11]([CH3:12])[CH2:10][CH2:9][N:5]4[C:6](=[O:8])[N:7]=3)=[CH:27][C:24]=2[C:25]#[N:26])[CH:19]=[CH:18][N:17]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-oneHCID 86724213HCID 86724213, compound

Product 1

HCID 86724212HCID 86724212, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (65 mg, 0.350 mmol), sodium hydride (22 mg, 0.550 mmol) and 2-((2-chloropyridin-4-yl)oxy)-5-(hydroxymethyl)benzonitrile (91 mg, 0.350 mmol) in DMF (2 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-c19a0a68e4fb49efa57076123040a304
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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