Sodium hydride → HCID 71243759, compound

HRID 873227Notes

Reaction equation

HRID 873227 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][C:12]=2[C:19]#[N:20])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[H-].[Na+].Cl[C:24]1[CH:25]=[C:26]2[N:33]([CH3:34])[CH2:32][CH2:31][N:27]2[C:28](=[O:30])[N:29]=1>C1COCC1>[Cl:1][C:2]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][O:18][C:24]3[CH:25]=[C:26]4[N:33]([CH3:34])[CH2:32][CH2:31][N:27]4[C:28](=[O:30])[N:29]=3)=[CH:13][C:12]=2[C:19]#[N:20])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71236710HCID 71236710, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71243759HCID 71243759, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using 2-chloro-4-(2-cyano-4-(hydroxymethyl)phenoxy)benzonitrile (60 mg, 0.211 mmol) in THF (S mL), sodium hydride (12.64 mg, 0.316 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (39.1 mg, 0.211 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-9c2846d5f088428cbdb374f2de99ea65
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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