Sodium hydride → HCID 71241157, compound

HRID 873230Notes

Reaction equation

HRID 873230 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][C:12]=2[F:19])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[H-].[Na+].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>C1COCC1>[Cl:1][C:2]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][O:18][C:23]3[CH:24]=[C:25]4[N:32]([CH3:33])[CH2:31][CH2:30][N:26]4[C:27](=[O:29])[N:28]=3)=[CH:13][C:12]=2[F:19])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71241010HCID 71241010, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71241157HCID 71241157, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using 2-chloro-4-(2-fluoro-4-(hydroxymethyl)phenoxy)benzonitrile (100 mg, 0.360 mmol) in THF (8 mL), sodium hydride (21.6 mg, 0.540 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (66.8 mg, 0.360 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-0d3deb7d9cc64566ac8d5840c3aba94a
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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