Sodium hydride → HCID 86724182, compound

HRID 873239Notes

Reaction equation

HRID 873239 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:10][OH:11])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].[H-].[Na+].Cl[C:15]1[CH:16]=[C:17]2[N:24]([CH3:25])[CH2:23][CH2:22][N:18]2[C:19](=[O:21])[N:20]=1>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:9])[C:7]=1[F:8])[CH2:10][O:11][C:15]1[CH:16]=[C:17]2[N:24]([CH3:25])[CH2:23][CH2:22][N:18]2[C:19](=[O:21])[N:20]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 53414454HCID 53414454, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 86724182HCID 86724182, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using (3-chloro-4,5-difluorophen-yl)methanol (192 mg, 1.078 mmol) in DMF (4 mL), sodium hydride (129 mg, 3.23 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (200 mg, 1.078 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-449f483bb0584371acf465dfcfe286e6
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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