Sodium hydride → HCID 71241052, compound

HRID 873240Notes

Reaction equation

HRID 873240 reaction equation
[F:1][C:2]1[CH:20]=[C:19]([CH2:21][OH:22])[CH:18]=[C:17]([F:23])[C:3]=1[O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[H-].[Na+].Cl[C:27]1[CH:28]=[C:29]2[N:36]([CH3:37])[CH2:35][CH2:34][N:30]2[C:31](=[O:33])[N:32]=1>CN(C=O)C>[F:1][C:2]1[CH:20]=[C:19]([CH2:21][O:22][C:27]2[CH:28]=[C:29]3[N:36]([CH3:37])[CH2:35][CH2:34][N:30]3[C:31](=[O:33])[N:32]=2)[CH:18]=[C:17]([F:23])[C:3]=1[O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-oneHCID 86724221HCID 86724221, compound

Product 1

HCID 71241052HCID 71241052, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 4-(2,6-difluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile (280 mg, 0.850 mmol) in DMF (5 mL), sodium hydride (61.2 mg, 2.55 mmol) and 7-chloro-1-methyl-2,3-dih-ydroimidazo[1,2-c]pyrimidin-5(1H)-one (158 mg, 0.850 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-a22cb19d64ce43bab58209d925d5be9b
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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