Sodium hydride → HCID 71241117, compound

HRID 873243Notes

Reaction equation

HRID 873243 reaction equation
[F:1][C:2]1[CH:17]=[C:16]([CH2:18][OH:19])[CH:15]=[CH:14][C:3]=1[O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([CH3:13])[CH:6]=1.[H-].[Na+].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>CN(C=O)C>[F:1][C:2]1[CH:17]=[C:16]([CH2:18][O:19][C:23]2[CH:24]=[C:25]3[N:32]([CH3:33])[CH2:31][CH2:30][N:26]3[C:27](=[O:29])[N:28]=2)[CH:15]=[CH:14][C:3]=1[O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([CH3:13])[CH:6]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71243819HCID 71243819, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71241117HCID 71241117, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 4-(2-fluoro-4-(hydroxymethyl)phenoxy)-2-methylbenzonitrile (1.00 g, 3.89 mmol) in DMF (10 mL), sodium hydride (0.280 g, 11.7 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]p-yrimidin-5(1H)-one (0.721 g, 3.89 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-eb199f541a6a41129a737dfb0c4e5a9d
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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