反应详情

1,1′-Carbonyldiimidazole (50.1 mg, 0.309 mol) was added to a solution of the 4-[4-methoxy-2-methyl-3-(3,3,6,6-tetramethyl-1,8-dioxo-2,3,4,5,6,7,8,9-octahydro-1H-xanthen-9-yl)phenyl]pyrimidine-2-carboxylic acid obtained in Example 75-4 (133 mg, 0.257 mmol) in THF (2.0 mL) and DMF (0.5 mL) at room temperature, and the mixture thus obtained was then stirred at the same temperature as above for 30 minutes. Thereafter, 27% ammonia water was added to the resulting solution, and the mixture thus obtained was further stirred at the same temperature as above for 30 minutes. Thereafter, water was added to the reaction solution, and the mixed solution was then extracted with ethyl acetate twice. The organic layer thus obtained was washed with 1 M-hydrochloric acid and brine, and was then dried over anhydrous sodium sulfate. After that, the solvent was distilled away under reduced pressure. The residue thus obtained was solidified with diethyl ether to obtain the title compound (114 mg, yield: 86%).

1. customthe mixture thus obtained
2. customthe mixture thus obtained
3. stirringwas further stirred at the same temperature as above for 30 minutes
4. extractionthe mixed solution was then extracted with ethyl acetate twice
5. customThe organic layer thus obtained
6. washwas washed with 1 M-hydrochloric acid and brine
7. dry with materialwas then dried over anhydrous sodium sulfate
8. distillationAfter that, the solvent was distilled away under reduced pressure
9. customThe residue thus obtained