Dimethylformamide → HCID 11368152, compound

HRID 874518Notes

Reaction equation

HRID 874518 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=O.C(Cl)(=O)C([Cl:14])=O.CN(C=O)C>C(Cl)Cl>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([Cl:14])=[O:10]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 1217237-Bromoheptanoic acid

Product 1

HCID 11368152HCID 11368152, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

to a suspension of 7-bromoheptanoic acid (1.7 g, 8.13 mmol) obtained above in CH2Cl2 (30 mL) were added oxalylchloride (2.13 mL, 24.39 mmol) and a catalytic amount of DMF. The mixture was stirred overnight at room temperature. The solvent was removed by evaporation in vacuo to give 1.84 g (100%) of the 7-bromoheptanoyl chloride as a yellow solid.

Workup

  1. customThe solvent was removed by evaporation in vacuo

Sources & evidence

ORD record
ord-fe3fa9c5d0fb40bb911a201ab89334cf
Source dataset
uspto-grants-2015_03
Patent number
US08980909B2

Reaction notes

Loading…