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HRID875172

反应详情

EQUATION

反应方程式

HRID 875172 的结构方程式

REACTANTS

反应物

8
结构：Cc1ccnc(C)c1
HCID7936

2,4-Dimethylpyridine

C7H9N

结构：Cc1cccc(C)n1
HCID7937

2,6-Dimethylpyridine

C7H9N

结构：Cc1ccncc1C
HCID11417

3,4-Dimethylpyridine

C7H9N

结构：Cc1cccnc1C
HCID11420

2,3-Dimethylpyridine

C7H9N

结构：Cc1ccc(C)nc1
HCID11526

2,5-Dimethylpyridine

C7H9N

结构：Cc1cncc(C)c1
HCID11565

3,5-Dimethylpyridine

C7H9N

结构：CCCCC(=O)Cl
HCID61186

Valeryl chloride

C5H9ClO

结构：COC(=O)[C@@H](NCc1ccc(-c2ccccc2C#N)cc1)C(C)C
HCID16744794

Methyl N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-L-valinate

C20H22N2O2

PRODUCTS

生成物

1
结构：CCCCC(=O)N(Cc1ccc(-c2ccccc2C#N)cc1)[C@H](C(=O)OC)C(C)C
HCID16744795

N-[(2′-Cyano[1,1′-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine methyl ester

C25H30N2O3

PROCEDURE

实验过程

Reacting pure N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VI) with n-valeryl chloride in the presence of a heterocyclic amine base selected from 2,6-lutidine, 2,4-lutidine, 2,3-lutidine, 3,4-lutidine, 2,5-lutidine, 3,5-lutidine to produce pure N-valeryl-N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VII) substantially free from alkene impurity of formula (VIIa).