Hydrochloric Acid → HCID 86673658, compound

HRID 876163Notes

Reaction equation

HRID 876163 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[Cl:9][C:10]1[CH:11]=[C:12]([CH:14]=[CH:15][CH:16]=1)[NH2:13].Cl>CC(O)C>[ClH:1].[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:13][C:12]2[CH:14]=[CH:15][CH:16]=[C:10]([Cl:9])[CH:11]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 79323-ChloroanilineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 86673658HCID 86673658, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
84 °C

Procedure

250 mg of 4,6-dichloropyrimidine and 165 mg of m-chloroaniline were dissolved in 2.5 mL of i-PrOH and 0.25 mL of 37% HCl were added. The mixture obtained was refluxed (84° C.) for 2.5 hours under nitrogen atmosphere. A colorless precipitate was formed which was collected by filtration. 6-Chloro-N-(3-chlorophenyl)pyrimidin-4-amine hydrochloride in the form of colorless crystals was obtained.

Workup

  1. customThe mixture obtained
  2. customA colorless precipitate was formed which
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-f5a7a0419ef84682836d9750ac7b4b97
Source dataset
uspto-grants-2015_03
Patent number
US08986994B2

Reaction notes

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