反应详情

A mixture containing (6-(tert-butoxycarbonylamino)pyridin-2-yl)methyl methanesulfonate 81 (1.30 g, 3.2 mmol), pyrrolidine 72 (0.46 g, 6.4 mmol) and K2CO3 (1.30 g, 9.6 mmol) in acetonitrile (15 mL) was stirred at room temperature for 12 h. Saturated aqueous NaHCO3 was added and the mixture was concentrated under reduced pressure. The resulting aqueous layer was extracted with EtOAc. The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure to afford 82 (0.75 g, 62% yield).

1. concentrationthe mixture was concentrated under reduced pressure
2. extractionThe resulting aqueous layer was extracted with EtOAc
3. dry with materialThe combined organic layers were dried (Na2SO4)
4. concentrationconcentrated under reduced pressure