Hydrochloric Acid → HCID 67222333, compound

HRID 876570Notes

Reaction equation

C([O:4][C@@H:5]([C:30]([NH:32][C:33]1[CH:38]=[CH:37][C:36]([C:39]#[N:40])=[CH:35][CH:34]=1)=[O:31])[C@@H:6](CC([O-])=O)[C:7]([N:9]([C:17]1[CH:25]=[C:24]2[C:20]([CH:21]=[CH:22][NH:23]2)=[CH:19][CH:18]=1)[CH2:10][CH2:11][O:12]S(C)(=O)=O)=[O:8])(=O)C.C([O-])([O-])=O.[K+].[K+].Cl.O>CO.CCOCC>[C:39]([C:36]1[CH:37]=[CH:38][C:33]([NH:32][C:30](=[O:31])[C@H:5]([OH:4])[C@H:6]2[O:12][CH2:11][CH2:10][N:9]([C:17]3[CH:25]=[C:24]4[C:20]([CH:21]=[CH:22][NH:23]4)=[CH:19][CH:18]=3)[C:7]2=[O:8])=[CH:34][CH:35]=1)#[N:40]

Participants

Conditions

Temperature: 0 °C

Procedure

To a solution of compound 18-2 (0.34 g) in MeOH (10.2 mL), was added K2CO3 (272 mg) at 0° C. The reaction mixture was stirred at 0° C. overnight. Then 1N HCl (2 mL), H2O (5 mL) and Et2O (15 mL) were added into the reaction mixture. The precipitate was collected by filtration and was rinsed with H2O and Et2O to obtain compound 18-3 (40 mg) as a colorless amorphous solid.

Workup

filtrationThe precipitate was collected by filtration
washwas rinsed with H2O and Et2O

Sources & evidence

ORD record: ord-f8a9251871ed4bf6b44be0c8f799fd04
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987242B2

Reaction notes

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