反应详情

温度

0 °C

To a solution of compound 18-2 (0.34 g) in MeOH (10.2 mL), was added K2CO3 (272 mg) at 0° C. The reaction mixture was stirred at 0° C. overnight. Then 1N HCl (2 mL), H2O (5 mL) and Et2O (15 mL) were added into the reaction mixture. The precipitate was collected by filtration and was rinsed with H2O and Et2O to obtain compound 18-3 (40 mg) as a colorless amorphous solid.

1. filtrationThe precipitate was collected by filtration
2. washwas rinsed with H2O and Et2O