2-Hexanone → HCID 13434190, compound

HRID 878544Notes

Reaction equation

HRID 878544 reaction equation
[CH3:1][C:2](=[O:7])[CH2:3][CH2:4][CH2:5][CH3:6].[CH3:8][N:9]([CH:11](OC)OC)[CH3:10]>CN(C=O)C>[CH3:8][N:9]([CH3:11])/[CH:10]=[CH:1]/[C:2](=[O:7])[CH2:3][CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 115832-HexanoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 13434190HCID 13434190, compoundYield 19.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2-hexanone (2.0 g, 20 mmol) and DMF-DMA (2.4 g, 20 mmol) in DMF (10 mL) was stirred at 100° C. overnight. The reaction mixture was cooled, concentrated, and purified by flash column chromatography (PE/EtOAc=4:1˜2:1) to give the title compound (0.6 g, 19%) as yellow oil.

Workup

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated
  3. custompurified by flash column chromatography (PE/EtOAc=4:1˜2:1)

Sources & evidence

ORD record
ord-214bf7638bb24d66ad4df2311a2d5036
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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