Hydrochloric Acid → 5-Bromo-2-ethylbenzaldehyde

Temperature

-20 °C

To a solution of 4-bromo-1-ethyl-2-iodobenzene (31.8 g, 103 mmol) (described in WO 2008/071405) in anhydrous tetrahydrofuran (250 ml) at −20° C. is added isopropyl magnesium chloride (55 ml, 110 mmol, 2M solution in tetrahydrofuran) dropwise over 10 minutes. Once the addition is complete the reaction mixture is stirred at −20° C. for 3 hours, followed by dropwise addition of anhydrous N,N-dimethylformamide (16.0 ml, 200 mmol). The reaction mixture is stirred at room temperature for a further 2.5 hours, then left to stand overnight. 2M hydrochloric acid (90 ml) is added and the crude product is extracted into dichloromethane. Organics are combined, dried over magnesium sulfate then filtered and the filtrate evaporated under reduced pressure to afford 5-bromo-2-ethyl-benzaldehyde (21.20 g) as an orange liquid.

1. additionOnce the addition
2. stirringThe reaction mixture is stirred at room temperature for a further 2.5 hours
3. waitleft
4. waitto stand overnight
5. extractionthe crude product is extracted into dichloromethane
6. dry with materialdried over magnesium sulfate
7. filtrationthen filtered
8. customthe filtrate evaporated under reduced pressure

ORD record

ord-94842360bc3440afb630c7142c5c7c29

Source dataset

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08987476B2