Lithium Hydroxide → HCID 131732645, compound

HRID 882150Notes

Reaction equation

HRID 882150 reaction equation
[CH3:1][N:2]([CH3:11])[CH2:3]/[CH:4]=[C:5](\[CH3:10])/[C:6]([O:8]C)=[O:7].[Li+:12].[OH-]>O1CCCC1.O>[CH3:1][N:2]([CH3:11])[CH2:3]/[CH:4]=[C:5](\[CH3:10])/[C:6]([O-:8])=[O:7].[Li+:12]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 65648814HCID 65648814, compound

Product 1

HCID 131732645HCID 131732645, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

To methyl(2E)-4-(dimethylamino)-2-methylbut-2-enoate (238 mg, 1.51 mmol) in tetrahydrofuran (0.95 mL) and water (0.95 mL) was added LiOH (36 mg, 1.5 mmol). The solution was stirred at 40° C. for 4 hours before being frozen and lyophilized to afford a white semi-solid that was taken on to the next step as is. LRMS (ESI) calc'd for C7H13NO2 [M+]+: 144, found 144.

Workup

  1. temperaturebefore being frozen
  2. customto afford a white semi-solid that

Sources & evidence

ORD record
ord-0e0c467a966446f0a860022fd2feafd9
Source dataset
uspto-grants-2015_03
Patent number
US08993756B2

Reaction notes

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