Hydrochloric Acid → HCID 69454122, compound

HRID 882877Notes

Reaction equation

HRID 882877 reaction equation
[NH2:1][CH2:2][C:3]([S:6][C:7]1[N:15]([CH2:16][CH:17]=[C:18]([CH3:20])[CH3:19])[C:14]2[C:13](=[O:21])[N:12]([CH2:22][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:11](=[O:31])[N:10]([CH3:32])[C:9]=2[N:8]=1)([CH3:5])[CH3:4].[ClH:33]>C(OCC)(=O)C>[ClH:33].[NH2:1][CH2:2][C:3]([S:6][C:7]1[N:15]([CH2:16][CH:17]=[C:18]([CH3:19])[CH3:20])[C:14]2[C:13](=[O:21])[N:12]([CH2:22][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:11](=[O:31])[N:10]([CH3:32])[C:9]=2[N:8]=1)([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11547014HCID 11547014, compound

Product 1

HCID 69454122HCID 69454122, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

100 mg of 8-(2-amino-1,1-dimethylethylsulfanyl)-3-methyl-7-(3-methylbut-2-enyl)-1-(2-oxo-2-phenylethyl)-3,7-dihydropurine-2,6-dione were dissolved in 2 ml of ethyl acetate and treated with excess solution of hydrogen chloride in ethyl acetate. After concentration in vacuo at room temperature, the residue was stirred with 5 ml of diisopropyl ether, and the product was filtered off with suction and dried in a vacuum.

Workup

  1. concentrationAfter concentration in vacuo at room temperature
  2. filtrationthe product was filtered off with suction
  3. customdried in a vacuum

Sources & evidence

ORD record
ord-bd6f2563f2f24a95a7dcde65f01c6e64
Source dataset
uspto-grants-2012_08
Patent number
US08236810B2

Reaction notes

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