HCID 59253027, compound → HCID 59253102, compound

HRID 884754Notes

Reaction equation

HRID 884754 reaction equation
C(OC(=O)[N:7]([N:11]1[C:20]([CH2:21][Br:22])=[C:19]([C:23](=[O:37])[NH:24][C@@H:25]([CH:33]2[CH2:36][CH2:35][CH2:34]2)[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=2)[C:18]2[C:13](=[C:14]([F:38])[CH:15]=[CH:16][CH:17]=2)[C:12]1=[O:39])[CH2:8][CH2:9][CH3:10])(C)(C)C>ClCCCl.FC(F)(F)C(O)=O>[CH:33]1([C@H:25]([NH:24][C:23]([C:19]2[C:18]3[C:13](=[C:14]([F:38])[CH:15]=[CH:16][CH:17]=3)[C:12](=[O:39])[N:11]([NH:7][CH2:8][CH2:9][CH3:10])[C:20]=2[CH2:21][Br:22])=[O:37])[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=2)[CH2:36][CH2:35][CH2:34]1

Participants

4

Reactant 1

HCID 59253027HCID 59253027, compound

Product 1

HCID 59253102HCID 59253102, compound

Reagents, catalysts & solvents 2

HCID 111,2-DichloroethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

0.15 mg (3-Bromomethyl-4-{[(S)-cyclobutyl-(3-fluoro-phenyl)-methyl]-carbamoyl}-8-fluoro-1-oxo-1H-isoquinolin-2-yl)-propyl-carbamic acid tert-butyl ester was stirred at room temperature over night in 2 mL 1,2-dichloroethane and 2 mL trifluoroacetic acid. The reaction mixture was concentrated in vacuo to give the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-31efc7d8a42a4bd4b1a3ef49a47437b9
Source dataset
uspto-grants-2012_08
Patent number
US08242134B2

Reaction notes

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