Iodine → HCID 68721362, compound

To a cold (−78° C.) solution of thiazole (2.0 mL, 28.2 mmol) in tetrahydrofuran (140 mL) was added n-butyllithium (11.4 mL, 28.2 mmol, 2.48 M in hexane) dropwise. After 15 minutes, dihydro-2H-pyran-4(3H)-one (2.59 mL, 28.2 mmol) was added in a single portion. After 30 minutes, n-butyllithium (11.4 mL, 28.2 mmol, 2.48 M in hexane) was added dropwise. The reaction was allowed to stir for an additional 20 minutes, after which a solution of iodine (7.24 g, 28.2 mmol) in tetrahydrofuran (15 mL) was added dropwise. The reaction was then quenched by the addition of saturated aqueous Na2S2O3 and ethyl acetate (100 mL) and allowed to warm to ambient temperature. The layers were separated, and the aqueous was extracted with additional ethyl acetate (2×100 mL). The combined organics were dried with anhydrous Na2SO4, filtered, and concentrated to give a dark solid. Trituration of the residue with dichloromethane gave the title compound as a beije solid. MS (ESI) m/z 312[M+H]+.

1. waitAfter 30 minutes
2. customThe reaction was then quenched by the addition of saturated aqueous Na2S2O3 and ethyl acetate (100 mL)
3. customThe layers were separated
4. extractionthe aqueous was extracted with additional ethyl acetate (2×100 mL)
5. dry with materialThe combined organics were dried with anhydrous Na2SO4
6. filtrationfiltered
7. concentrationconcentrated
8. customto give a dark solid

ORD record

ord-dff4d35d9643428e947dc0cab999dd74

Source dataset

uspto-grants-2012_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08242139B2