反应详情

A 500-mL four-necked flask equipped with a mechanical stirrer, thermocouple, condenser, side-arm addition funnel and sodium hydroxide/sodium hypochlorite scrubber was charged with 2-amino-5-bromo-N,3-dimethylbenzamide (prepared by the method of Reference Example 1) (24.6 g, 0.10 mol, 99% purity) and mesitylene (100 g) while maintaining an atmosphere of nitrogen through a gas inlet line connected to the condenser. The reaction mixture was stirred at room temperature and sodium cyanide (ground to a powder just prior to use) (6.2 g, 0.121 mol, assuming, 95% purity), copper(I) iodide (2.9 g, 0.015 mol, 98% purity) and 1-butyl-1H-imidazole (5.4 g, 0.0425 mol, 98% purity) were added, after which time the nitrogen inlet line was attached directly to the reaction flask. The reaction mixture was heated at reflux (about 166-170° C.) for 6 h, while venting through the scrubber. After cooling overnight, water (100 mL) was added to the reaction mixture and stirring was continued for 1 h. Ethylenediamine (0.09 g, about 0.015 mol, 99% purity) was added to the reaction mixture, and stirring was continued for an additional 3.5 h. The mixture was filtered, and the solid collected was washed with water (3×50 mL), mesitylene (50 g) and dried to a constant weight in a vacuum-oven at 55° C. to give the title compound as a light brown solid (19.0 g).

1. customA 500-mL four-necked flask equipped with a mechanical stirrer
2. additionthermocouple, condenser, side-arm addition funnel
3. temperaturewhile maintaining an atmosphere of nitrogen through a gas inlet line
4. temperatureThe reaction mixture was heated
5. temperatureat reflux (about 166-170° C.) for 6 h
6. temperatureAfter cooling overnight
7. stirringstirring
8. stirringstirring
9. waitwas continued for an additional 3.5 h
10. filtrationThe mixture was filtered
11. customthe solid collected
12. washwas washed with water (3×50 mL), mesitylene (50 g)
13. customdried to a constant weight in a vacuum-oven at 55° C.