Hydroxide → 2,6-Difluoro-N-{3-[3-(2-{[3-({[2-(methylsulfonyl)ethyl]amino}methyl)-phenyl]amino}-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}benzamide
Reaction equation
[CH2:57]1[O:58][CH2:59][CH2:60][CH2:61]1.[CH3:63][CH2:64][O:65][C:66]([CH3:67])=[O:68].[F:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][c:7]2[cH:8][c:9](-[c:13]3[n:14][n:15]4[c:16]([cH:17][cH:18][cH:19][cH:20]4)[c:21]3-[c:22]3[n:23][c:24]([NH:28][c:29]4[cH:30][c:31]([CH2:35][N:36]([C:37](=[O:38])[C:39]([F:40])([F:41])[F:42])[CH2:43][CH2:44][S:45](=[O:46])(=[O:47])[CH3:48])[cH:32][cH:33][cH:34]4)[n:25][cH:26][cH:27]3)[cH:10][cH:11][cH:12]2)[c:49]([F:53])[cH:50][cH:51][cH:52]1.[Li+:55].[OH-:54].[OH2:56].[OH2:62]>>[F:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][c:7]2[cH:8][c:9](-[c:13]3[n:14][n:15]4[c:16]([cH:17][cH:18][cH:19][cH:20]4)[c:21]3-[c:22]3[n:23][c:24]([NH:28][c:29]4[cH:30][c:31]([CH2:35][NH:36][CH2:43][CH2:44][S:45](=[O:46])(=[O:47])[CH3:48])[cH:32][cH:33][cH:34]4)[n:25][cH:26][cH:27]3)[cH:10][cH:11][cH:12]2)[c:49]([F:53])[cH:50][cH:51][cH:52]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-b5311820f12b44a9ba119de5d6f59043
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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