Hydrochloric Acid → 4-amino-N-[1-(2,2-difluoro-ethyl)-piperidin-4-yl]-3-methoxy-benzamide

HRID 88681Notes

Reaction equation

HRID 88681 reaction equation
[CH3:35][N:36]([CH3:37])[CH:38]=[O:39].[CH3:40][CH2:41][N:42]([CH2:43][CH3:44])[CH2:45][CH3:46].[Cl:47][CH2:48][Cl:49].[ClH:22].[ClH:23].[F:24][CH:25]([CH2:26][N:27]1[CH2:28][CH2:29][CH:30]([NH2:33])[CH2:31][CH2:32]1)[F:34].[n:1]1([O:2][C:11]([c:12]2[cH:13][c:14]([O:19][CH3:20])[c:15]([NH2:18])[cH:16][cH:17]2)=[O:21])[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[n:9][n:10]1>>[C:11]([c:12]1[cH:13][c:14]([O:19][CH3:20])[c:15]([NH2:18])[cH:16][cH:17]1)(=[O:21])[NH:33][CH:30]1[CH2:29][CH2:28][N:27]([CH2:26][CH:25]([F:24])[F:34])[CH2:32][CH2:31]1

Participants

7

Reactant 6

HCID 313Hydrochloric Acid2×HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 106606854-Amino-3-methoxy-benzoic acid benzotriazol-1-yl esterHCID 252523891-(2,2-Difluoroethyl)-4-piperidinamine

Product 1

HCID 580151184-amino-N-[1-(2,2-difluoro-ethyl)-piperidin-4-yl]-3-methoxy-benzamide

Sources & evidence

ORD record
ord-0182557a33ef4020b10bcf188a89b2f5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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