Hydrochloric Acid → HCID 57907537, compound

HRID 887100Notes

Reaction equation

HRID 887100 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH:14]([CH2:20][CH2:21][F:22])[C:15]([O:17]CC)=[O:16])[N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Li+].Cl>C1COCC1.CO>[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH:14]([CH2:20][CH2:21][F:22])[C:15]([OH:17])=[O:16])[N:13]=1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 57907450HCID 57907450, compound

Product 1

HCID 57907537HCID 57907537, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the product from step B (100 mg, 0.3 mmol) in a mixture of THF (1 mL) and methanol (0.3 mL) was added a solution of lithium hydroxide (0.3 mL of a 1 M soln, 0.3 mmol) and the resulting mixture stirred at room temperature for 90 min. 1N HCl (0.3 mL, 0.3 mmol) was added and the mixture evaporated to dryness. The resulting crude product was used immediately without purification.

Workup

  1. customthe mixture evaporated to dryness
  2. customThe resulting crude product was used immediately without purification

Sources & evidence

ORD record
ord-065b77521c614b958b88d4eaff4fea91
Source dataset
uspto-grants-2012_08
Patent number
US08247415B2

Reaction notes

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