反应详情

温度

170 °C

2-tert-Butyl-phenylamine and bis-(2-chloro-ethyl)-methylamine were mixed together with K2CO3 (25 g), NaI (10 g) and diglyme (250 mL) and heated at 170° C. for 8 h. The reaction mixture was cooled, the solid filtered and solvent evaporated. The residue was diluted with EtOAc, washed with NaHCO3 solution, extracted twice more with EtOAc, washed with brine, dried over Na2SO4 and evaporated to give the compound as a dark solid.

1. temperatureThe reaction mixture was cooled
2. filtrationthe solid filtered
3. customsolvent evaporated
4. additionThe residue was diluted with EtOAc
5. washwashed with NaHCO3 solution
6. extractionextracted twice more with EtOAc
7. washwashed with brine
8. dry with materialdried over Na2SO4
9. customevaporated