反应详情

2-Amino-4-nitro-phenol (3.08 g, Aldrich) was stirred with THF (30 ml, Aldrich) in an ice bath. 2-Bromo-2-methyl-propionyl bromide (2.47 ml, Aldrich) and Et3N (2.0 g, Aldrich) was slowly added via syringe. The mixture was stirred for 45 min then poured into ice. The aqueous phase was extracted by EtOAc (50 mL×4). The organic layer was dried and concentrated. The desired compound was crystallized from EtOAc (Chem. Pharm. Bull 1996, 44(1) 103-114).

1. additionthen poured into ice
2. extractionThe aqueous phase was extracted by EtOAc (50 mL×4)
3. customThe organic layer was dried
4. concentrationconcentrated
5. customThe desired compound was crystallized from EtOAc (Chem. Pharm. Bull 1996, 44(1) 103-114)