HRID887684

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81349

4-Methyl-1-piperazinamine

C5H13N3

HCID892769

未命名化合物

结构：COC1=CC(=O)c2c(O)c3c(c(O)c2C1=O)C(=O)[C@]1(CCc2cc4cc(C=O)[nH]c(=O)c4c(O)c21)C3=O

HCID178493334

未命名化合物

PRODUCTS

生成物

结构：COC1=CC(=O)c2c(O)c3c(c(O)c2C1=O)C(=O)C1(CCc2cc4cc(C=NNN5CCN(C)CC5)[nH]c(=O)c4c(O)c21)C3=O

HCID178493328

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

Five (5) mg (9.42 μmol) fredericamycin aldehyde (4) are dissolved in 500 μl DMF and 25 μl trifluoracetic acid. At room temperature, 1.30 mg (11.3 μmol) 1-amino-4-methyl-piperazine is added. After stirring for 4.5 h at room temperature, 1 equivalent each of Wang aldehyde resin and sulfonohydrazide resin is added and stirred for 2 h.

WORKUP

后处理

stirringstirred for 2 h.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0d9dc9f5c05a4e5695b918cc8efa750d
来源数据集: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08247424B2
来源说明: uspto-grants-2012_08

反应 SMILES

[OH:1][C:2]1[C:11]2[C:10](=[O:12])[C:9]([O:13][CH3:14])=[CH:8][C:7](=[O:15])[C:6]=2[C:5]([OH:16])=[C:4]2[C:17](=[O:37])[C@:18]3([C:32]4[C:31]([OH:33])=[C:30]5[C:25]([CH:26]=[C:27]([CH:35]=O)[NH:28][C:29]5=[O:34])=[CH:24][C:23]=4[CH2:22][CH2:21]3)[C:19](=[O:20])[C:3]=12.[NH2:38][N:39]1[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]1.C1C=CC(C[NH:53]C(CN2C3C(=CC=CC=3)C(C=O)=C2)=O)=CC=1>CN(C=O)C.FC(F)(F)C(O)=O>[CH3:45][N:42]1[CH2:43][CH2:44][N:39]([NH:38][N:53]=[CH:35][C:27]2[NH:28][C:29](=[O:34])[C:30]3[C:25]([CH:26]=2)=[CH:24][C:23]2[CH2:22][CH2:21][C:18]4([C:17](=[O:37])[C:4]5=[C:5]([OH:16])[C:6]6[C:7](=[O:15])[CH:8]=[C:9]([O:13][CH3:14])[C:10](=[O:12])[C:11]=6[C:2]([OH:1])=[C:3]5[C:19]4=[O:20])[C:32]=2[C:31]=3[OH:33])[CH2:40][CH2:41]1