反应详情

温度

80 °C

To a solution of methyl 6-(3-methoxy-3-oxopropyl)-2-methyl-1H-benzimidazole-7-carboxylate (417 mg, 1.51 mmol) in acetonitrile (15 mL) were added potassium carbonate (62.6 mg, 0.453 mmol) and benzyl bromide (269 μL, 2.26 mmol), and the mixture was stirred at 80° C. for 3 hr. The reaction solution was diluted with saturated aqueous sodium hydrogen carbonate solution, extracted with ethyl acetate, washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/ethyl acetate=0/100→5/95) to give the title compound (164 mg, yield 30%).

1. extractionextracted with ethyl acetate
2. washwashed with water and saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (methanol/ethyl acetate=0/100→5/95)