反应详情

温度

80 °C

To a solution of methyl 3-bromo-5-(5-chloropyridin-2-yl)benzoate (78.0 mg, 0.24 mmol)) in DMF (1.2 mL) and water (0.4 mL) was 2-isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (53.9 μL, 0.29 mmol), palladium(II) acetate (2.68 mg, 0.012 mmol), 3,3′3″-phosphinidynetris(benzenesulfonic acid)trisodium salt (20.4 mg, 0.036 mmol) and diisopropylamine (85.0 μL, 0.60 mmol) and the mixture was heated to 80° C. After 1 h, the reaction was filtered and the filtrate was purified by reverse phase chromatography (C-18, 85% water/acetonitrile→5% water/acetonitrile with 0.1% trifluoroacetic acid) gave the title compound (59 mg). MS 388.0 (M+1).

1. filtrationthe reaction was filtered
2. customthe filtrate was purified by reverse phase chromatography (C-18, 85% water/acetonitrile→5% water/acetonitrile with 0.1% trifluoroacetic acid)