Isopropanol → Diisopropylethylamine

HRID 888963Notes

Reaction equation

N1C=CC=N[CH:2]=1.C([N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])C.[CH:14](O)([CH3:16])[CH3:15]>>[CH:14]([N:9]([CH:10]([CH3:11])[CH3:2])[CH2:12][CH3:13])([CH3:16])[CH3:15]

Participants

Reactant 3

HCID 3776Isopropanol

HCID 8471Triethylamine

HCID 9260Pyrimidine

Product 1

HCID 81531Diisopropylethylamine

Procedure

The starting pyrimidine (a) is reacted with an appropriately substituted amine and a suitable base such as diisopropylethylamine or triethylamine in a suitable solvent such as isopropanol at elevated temperature to provide compound (b).

Sources & evidence

ORD record: ord-069e0cbac8214ce5a18ebcfc0dee2ceb
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08252798B2

Reaction notes

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