Propylamine → HCID 22692581, compound

HRID 889078Notes

Reaction equation

HRID 889078 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:13]([NH2:16])[CH2:14][CH3:15].C(N(CC)CC)C>C(#N)C.C(OCC)(=O)C>[Cl:1][C:2]1[N:11]=[C:10]([NH:16][CH2:13][CH2:14][CH3:15])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

6

Reactant 3

HCID 7852PropylamineHCID 8471TriethylamineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 22692581HCID 22692581, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8857Ethyl AcetateSolvent

Procedure

2,4-Dichloroquinazoline (600 mg, 3.01 mmol) was dissolved in acetonitrile (10 mL). Propylamine (200 mg, 3.3 mmol) and triethylamine (2.1 mL, 15 mmol) were added. The mixture was stirred at room temperature over-night. Filtration and evaporation of the filtrate gave a yellow solid, which was dissolved in ethyl acetate and washed three times with water. Drying (magnesium sulphate), filtration and evaporation gave (2-chloro-quinazolin-4-yl)-propylamine as a yellow solid.

Workup

  1. filtrationFiltration and evaporation of the filtrate
  2. customgave a yellow solid, which
  3. washwashed three times with water
  4. customDrying
  5. filtration(magnesium sulphate), filtration and evaporation

Sources & evidence

ORD record
ord-c94d55d543ee48eb902e756201202792
Source dataset
uspto-grants-2012_08
Patent number
US08252806B2

Reaction notes

Loading…