Triethylamine hydrochloride → HCID 178505480, compound

HRID 889395Notes

Reaction equation

HRID 889395 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH:13]([CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][O:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][C:17]=3[F:24])=[C:11]3[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:10]3=[N:9]2)=[CH:4][CH:3]=1.[N-:36]=[N+:37]=[N-:38].[Na+].Cl.C(N(CC)CC)C>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([CH:13]([CH:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]3)[CH2:14][O:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]4[NH:38][N:37]=[N:36][N:21]=4)=[CH:18][C:17]=3[F:24])=[C:11]3[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:10]3=[N:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 53390441HCID 53390441, compound

Product 1

HCID 178505480HCID 178505480, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 5, 4-{2-[2-(4-chloro-phenyl)-2,4,5,6,7,8-hexahydro-cycloheptapyrazol-3-yl]-2-cyclohexyl-ethoxy}-3-fluoro-benzonitrile (example 14.2) was treated with sodium azide and triethylamine hydrochloride in DMF to give the title compound as white solid. MS: m/e=535.7 [M+H+].

Sources & evidence

ORD record
ord-cd4351fa07e34cc29cd78423770ec8d8
Source dataset
uspto-grants-2012_08
Patent number
US08252826B2

Reaction notes

Loading…