反应详情

温度

80 °C

After dissolving 230 mg of 2-methylphenol in 20 ml of N,N-dimethylformamide, 43 mg of sodium hydride (70% suspension in oil) was added and the mixture was stirred at 80° C. for 30 minutes. Next, 224 mg of 1-(tert-butoxycarbonyl)-4-cyano-4-(methanesulfonyloxymethyl)piperidine was added and the mixture was stirred at 100° C. for 8 hours. After cooling it to room temperature, water was added and extraction was performed with ethyl acetate. The organic layer was washed with a 1N sodium hydroxide solution and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (273 mg, 100% yield).

1. additionwas added
2. stirringthe mixture was stirred at 100° C. for 8 hours
3. temperatureAfter cooling it to room temperature
4. extractionextraction
5. washThe organic layer was washed with a 1N sodium hydroxide solution
6. dry with materialdried over magnesium sulfate
7. distillationThe solvent was distilled off under reduced pressure