HRID890460

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID97268

Di-tert-butyl azodicarboxylate

C10H18N2O4

HCID21935831

未命名化合物

HCID68822476

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)Cn1ccc2c(OCCc3ccc(-c4ccc(C(F)(F)F)cc4)nc3C)cccc21

HCID69637726

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

In analogy to the procedure described in example 5 f], (4-hydroxy-indol-1-yl)-acetic acid ethyl ester was reacted with 2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol (example 8 e]) in the presence of di-tert-butyl azodicarboxylate and triphenylphosphine in tetrahydrofuran to yield the title compound as white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a76c169f15af4c158df079acdbecde46
来源数据集: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06995263B2
来源说明: uspto-grants-2006_02

反应 SMILES

[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([OH:15])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].[CH3:17][C:18]1[C:23]([CH2:24][CH2:25]O)=[CH:22][CH:21]=[C:20]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=2)[N:19]=1.N(C(OC(C)(C)C)=O)=NC(OC(C)(C)C)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([O:15][CH2:25][CH2:24][C:23]3[C:18]([CH3:17])=[N:19][C:20]([C:27]4[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:34])[F:35])=[CH:29][CH:28]=4)=[CH:21][CH:22]=3)[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]